Publicaciones

2017

1. Beatriz Valenzuela, Javiera Obreque, Sarita Soto-Aguilera, Kevin Maisey, Mónica Imarai, Brenda Modak. Key cytokines of adaptive immunity are differentially induced in rainbow trout kidney by a group of structurally related geranyl aromatic derivatives. Fish & Shellfish Immunology 2016. 49: 45-53

2. Kevin Maisey, Ruth Montero, Yolanda Corripio-Miyar, Daniela Toro-Ascuy, Beatriz Valenzuela, Sebastián Reyes-Cerpa, Ana María Sandino, Jun Zou, Tiehui Wang, Christopher J. Secombes and Mónica Imarai. Isolation and characterization of salmonid CD4+ T cells. J of Immunology. 2016. 196: 4150-4163.

3. Felipe E Rodríguez, Beatriz Valenzuela, Ana Farías, Ana María Sandino, Mónica Imarai. β-1,3/1,6-glucan supplemented diets antagonize immune inhibitory effects of hypoxia and enhance the immune response to a model vaccine, Fish & Shellfish Immunology 2016. 59:36-45.

4. Mick Parra, Beatriz Valenzuela, Mónica Imarai, Brenda Modak. Obtainment and evaluation of adjuvant effect of the aromatic geranyl derivative Filifolinone in bacterin of Piscirickettsia salmonis. Journal of Fish Diseases 2017 Jul 24. doi: 10.1111/jfd.12669.

5. Alvaro. Sequeida, Kevin Maisey, Mónica Imarai. Interleukin 4/13 receptors: An overview of genes, expression and functional role in teleost fish. Cytokine & Growth Factor Reviews 2017. https://doi.org/10.1016/j.cytogfr.2017.09.004

6. Morales, Jonathan; Barrera-Avalos, Carlos; Castro, Carlos; Castillo, Stephanie; Barrientos, Claudio; Robles-Planells, Claudia; Lopez, Ximena; Torres, Ernesto; Montoya, Margarita; Cortez-San Martin Marcelo; Riquelme, Denise; Escobar, Alejandro; Fernández, Ricardo; Imarai, Monica; Sauma, Daniela; et. al. Dead Tumor Cells expressing ISAV fusogenic protein favor antigen cross-priming in vitro. 2017 Frontiers in Immunology (1664-3224) doi: 10.3389/fimmu.2017.01170

7 Alamos P, Tello M, Bustamante P, Gutiérrez F, Shmaryahu A, Maldonado J, et al. Functionality of tRNAs encoded in a mobile genetic element from an acidophilic bacterium. RNA Biol. 2017; doi:10.1080/15476286.2017.1349049

8. Caamaño E, Loperena L, Hinzpeter I, Pradel P, Gordillo F, Corsini G, et al. Isolation and molecular characterization of Thraustochytrium strain isolated from Antarctic Peninsula and its biotechnological potential in the production of fatty acids. Brazilian J Microbiol. 2017; doi:10.1016/j.bjm.2017.01.011

9. Rojas-Aedo JF, Gil-Durán C, Del-Cid A, Valdés N, Álamos P, Vaca I, et al. The Biosynthetic Gene Cluster for Andrastin A in Penicillium roqueforti. Front Microbiol. 2017;8: 813. doi:10.3389/fmicb.2017.00813

2016

Publicaciones aceptadas

• Beatriz Valenzuela, Javiera Obreque, Sarita Soto-Aguilera, Kevin Maisey, Mónica Imarai, Brenda Modak. Key cytokines of adaptive immunity are differentially induced in rainbow trout kidney by a group of structurally related geranyl aromatic derivatives. Fish & Shellfish Immunology 2016. 49: 45-53

• Kevin Maisey, Ruth Montero, Yolanda Corripio-Miyar, Daniela Toro-Ascuy, Beatriz Valenzuela, Sebastián Reyes-Cerpa, Ana María Sandino, Jun Zou, Tiehui Wang, Christopher J. Secombes and Mónica Imarai. Isolation and characterization of salmonid CD4+ T cells. J of Immunology. 2016. 196: 4150-4163.

• Maisey K, Montero M, Christodoulides. Vaccines for piscirickettsiosis (salmonid rickettsial septicaemia, SRS): the Chile perspective. Exp Review Vacc. 2016. En prensa.

• Ruben Avendaño-Herrera, Rute Irgang, Matías Poblete-Morales, Yesseny Vásquez-Martínez, Claudia Robles, Daniela Toro-Ascuy & *Marcelo Cortez-San Martín. Predominant bacteria associated with black rockcod (Notothenia coriiceps, Richardson 1844) from King George Island, Antarctica. EAFP Bulletin. Aceptado.

• Mick Parra, Beatriz Valenzuela, Sarita Soto & Brenda Modak. Antibacterial activity of cuticular components from Heliotropium species, against Staphylococcus aureus and Salmonella tiphymurium. Blacpma 2016. 15(6):422-428.

• Gino Corsini, Natalia Valdés, Paulina Pradel, Mario Tello, Luis Cottet, Laura Muiño, Eduardo Karahanian, Antonio Castillo, Alex R. Gonzalez: Draft Genome Sequence of a Copper-Resistant Marine Bacterium, Pantoea agglomerans Strain LMAE-2, a Bacterial Strain with Potential Use in Bioremediation. Genome Announcements 06/2016; 4(3). DOI:10.1128/genomeA.00525-16

• María José Vargas-Straube, Beatriz Cámara, Mario Tello, Francisco Montero-Silva, Franco Cárdenas, Michael Seeger: Genetic and Functional Analysis of the Biosynthesis of a Non-Ribosomal Peptide Siderophore in Burkholderia xenovorans LB400. PLoS ONE 03/2016; 11(3). DOI:10.1371/journal.pone.0151273

• Dante Miranda, Claudia Jara, Jorge Ibañez, Viviana Ahumada, Claudio Acuña-Castillo, Adrian Martin, Alexandra Cordova, and Margarita Montoya. PGC1a-dependent mitochondrial adaptation is necessary to sustain IL-2-induced activities in human NK cells. Mediators of Inflammation. 2016; 2016:9605253.

• Dominique Fernández, Felipe Flores-Santibáñez, Jocelyn Neira, Francisco Osorio, Gabriela Tejón, Sarah Nuñez, Yessia Hidalgo, María José Fuenzalida, Daniel Meza, Gonzalo Ureta, Álvaro Lladser, Rodrigo Pacheco, Claudio Acuña-Castillo, Victoria Guixé1, Francisco J. Quintana, María Rosa Bono, Mario Rosemblatt, Daniela Sauma. Purinergic Signaling as a Regulator of Th17 Cell Plasticity. PLoS One 2016;11(6):e0157889.

Publicaciones en revisión o enviadas

• Felipe E. Rodríguez, Beatriz Valenzuela, Ana Farías, Ana María Sandino, Mónica Imarai. β-1,3/1,6-glucan supplemented diets antagonize immune inhibitory effects of hypoxia and enhance the immune response to a model vaccine, Fish & Shellfish Immunology 2016. Revised.

• Sebastián Reyes-Cerpa, Eva Vallejos-Vidal, Maria Jose Gonzalez-Bown, Jonathan Morales-Reyes, Monica Imarai, Amanda Carrasco-Malio, Ali Khansari, Victor Cifuentes, Eugenio Spencer, Felipe Reyes-Lopez, Ana María Sandino. Effect of yeast (Xanthophyllomyces dendrorhous) and plant (Saint John's wort, lemon balm, and rosemary) extract based functional diets on antioxidant and immune status of Atlantic salmon (Salmo salar) subjected to crowding stress. Fish & Shellfish Immunology 2016. Submitted

• Journal: Brazilian Journal of Microbiology. Title: Isolation and Molecular Characterization of Thraustochytrium strain isolated from Pensinsula Antarctic and its biotechnological potential in the production of fatty acids. Authors: Esteban Caamaño, Paulina Pradel, Mario Tello, Gino Corsini, Milka L Loperena, Paris Lavin, Ivonne Hinzpeter, Felipe Gordillo, Alex Gonzalez.

• Rivas-Aravena A., Muñoz P., Jorquera P., Reinoso C., González- Catrilelbún S. and Sandino A.M. The translation initiation of mRNA-A of Infectious Pancreatic Necrosis Virus (IPNV) is IRES-dependent. Viruses 2016. Revised.

2015

Development of a nanoparticle-based oral vaccine for Atlantic salmon against ISAV using an alphavirus replicon as adjuvant. Rivas-Aravena, A.,Fuentes,Y., Cartagena, J., Brito, T., Poggio, V., Latorre, J., Mendoza,H., Gonzalez-Nilo, F., Sandino,A.M., and Spencer. E. Fish & Shellfish Immunology, 45:157-166. 2015

Ribavirin stimulate the immune response of Atlantic salmon.. Rivas-Aravena A, Guajardo S, Valenzuela B, Cartagena J, Imarai MI, Spencer E, Sandino AM. Veterinary Immunology and Immunopathology. 164: 93-100. 2015

Valenzuela.B, Imarai.M, Catalán.R, Parra.M, Soto.S, Sandino.A, Torres.R, Modak.B.“Evaluation of the bactericidal activity of secondary metabolites isolated from Heliotropium genus against Piscirickettsia salmonis”. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 14, 131-140, 2015.

Ruben Avendaño-Herrera, Rute Irgang, Matías Poblete-Morales, Yesseny Vásquez-Martínez, Claudia Robles, Daniela Toro-Ascuy & *Marcelo Cortez-San Martín. Predominant bacteria associated with the Antarctic black rock cod (Notothenia coriiceps, Richardson 1844) from King George Island (Southern Shetlands) in the Antarctica. Polar Biology. En revisión Submission number: POBI-D-15-00027.

Ivonne Lozano, Jaime Carrasco, Jurij M Wacyk and Marcelo Cortez-San Martin. Red macro algae Pyropia columbina and Gracilaria chilensis: sustainable feed additive in Salmo salar diet, and the evaluation of potential anti-viral activity against infectious salmon anemia virus (ISAV). Journal of Applied Phycology. Publicado 30 Jun 2015.DOI 10.1007/s10811-015-0648-8.

Beatriz Valenzuela, Javiera Obreque, Sarita Soto-Aguilera, Kevin Maisey, Mónica Imarai, Brenda Modak. "Key cytokines of adaptive immunity are differentially induced in rainbow trout kidney by a group of structurally related geranyl aromatic derivatives" DOI 10.1016/j.fsi.2015.12.008.

Cappelli C, López X, Labra Y, Montoya M, Fernández R, Imarai M, et al. Polymyxin B increases the depletion of T regulatory cell induced by purinergic agonist. Immunobiology. 2012;217: 307–15. doi:10.1016/j.imbio.2011.10.006

Escobar A, Candia E, Reyes-Cerpa S, Villegas-Valdes B, Neira T, Lopez M, et al. Neisseria gonorrhoeae induces a tolerogenic phenotype in macrophages to modulate host immunity. Mediators Inflamm. 2013;2013: 127017. doi:10.1155/2013/127017

Reyes-Cerpa S, Reyes-López F, Toro-Ascuy D, Montero R, Maisey K, Acuña-Castillo C, et al. Induction of anti-inflammatory cytokine expression by IPNV in persistent infection. Fish Shellfish Immunol. 2014;41: 172–82. doi:10.1016/j.fsi.2014.08.029

Fernandez R, Nardocci G, Navarro C, Reyes EP, Acuña-Castillo C, Cortes PP. Neural reflex regulation of systemic inflammation: potential new targets for sepsis therapy. Front Physiol. 2014;5: 489. doi:10.3389/fphys.2014.00489

Nardocci G, Navarro C, Cortés PP, Imarai M, Montoya M, Valenzuela B, et al. Neuroendocrine mechanisms for immune system regulation during stress in fish. Fish Shellfish Immunol. 2014;40: 531–8. doi:10.1016/j.fsi.2014.08.001

M. Cortez-San Martín, R. A. Villanueva, M. Jashés, and A. M. Sandino, “Molecular characterization of IPNV RNA replication intermediates during the viral infective cycle.,” Virus Res., vol. 144, no. 1–2, pp. 344–9, Sep. 2009.

L. Cottet, M. Cortez-San Martin, M. Tello, E. Olivares, A. Rivas-Aravena, E. Vallejos, A. M. Sandino, and E. Spencer, “Bioinformatic analysis of the genome of infectious salmon anemia virus associated with outbreaks with high mortality in Chile.,” J. Virol., vol. 84, no. 22, pp. 11916–28, Nov. 2010.

B. Modak, A. M. Sandino, L. Arata, G. Cárdenas-Jirón, and R. Torres, “Inhibitory effect of aromatic geranyl derivatives isolated from Heliotropium filifolium on infectious pancreatic necrosis virus replication.,” Vet. Microbiol., vol. 141, no. 1–2, pp. 53–8, Feb. 2010.

L. Cottet, A. Rivas-Aravena, M. Cortez-San Martin, A. M. Sandino, and E. Spencer, “Infectious salmon anemia virus--genetics and pathogenesis.,” Virus Res., vol. 155, no. 1, pp. 10–9, Jan. 2011.

A. Rivas-Aravena, E. Vallejos-Vidal, M. Cortez-San Martin, F. Reyes-Lopez, M. Tello, P. Mora, A. M. Sandino, and E. Spencer, “Inhibitory effect of a nucleotide analog on infectious salmon anemia virus infection.,” J. Virol., vol. 85, no. 16, pp. 8037–8045, 2011.

B. Modak, A. Rivas, E. Vallejos, A. M. Sandino, and E. Spencer, “Antiviral activity in vitro and in vivo of natural flavonoids isolated from Heliotropium sinuatum against infectious salmon anemia virus (ISAV),” Boletín Latinoam. y del Caribe Plantas Med. y Aromáticas, vol. 11, no. 4, pp. 377–384, 2012.

S. Reyes-Cerpa, K. Maisey, F. Reyes-López, D. Toro-Ascuy, A. M. Sandino, and M. Imarai, “Fish Cytokines and Immune Response,” in New Advances and Contributions to Fish Biology, H. Turker, Ed. InTech, 2012.

A. Rivas-Aravena, M. Cortez-San Martin, J. Galaz, M. Imarai, D. Miranda, E. Spencer, and A. M. Sandino, “Evaluation of the immune response against immature viral particles of infectious pancreatic necrosis virus (IPNV): a new model to develop an attenuated vaccine.,” Vaccine, vol. 30, no. 34, pp. 5110–7, Jul. 2012.

S. Reyes-Cerpa, F. E. Reyes-López, D. Toro-Ascuy, J. Ibañez, K. Maisey, A. M. Sandino, and M. Imarai, “IPNV modulation of pro and anti-inflammatory cytokine expression in Atlantic salmon might help the establishment of infection and persistence.,” Fish Shellfish Immunol., vol. 32, no. 2, pp. 291–300, Feb. 2012.

M. Cortez-San Martin, A. Rivas-Aravena, S. Guajardo, M. T. Castillo, M. Jashes, A. M. Sandino, and E. Spencer, “Simultaneous detection of the IPN and ISA viruses in outbreaks of clinical disease and mortality in farmed Atlantic salmon, Salmo salar L., in Chile.,” J. Fish Dis., vol. 35, no. 6, pp. 461–5, Jun. 2012.

A. Rivas-Aravena, A. M. Sandino, and E. Spencer, “Nanoparticles and microparticles of polymers and polysaccharides to administer fish vaccines.,” Biol. Res., vol. 46, no. 4, pp. 407–19, Jan. 2013.

S. Reyes-Cerpa, F. Reyes-López, D. Toro-Ascuy, R. Montero, K. Maisey, C. Acuña-Castillo, J. O. Sunyer, D. Parra, A. M. Sandino, and M. Imarai, “Induction of anti-inflammatory cytokine expression by IPNV in persistent infection.,” Fish Shellfish Immunol., vol. 41, no. 2, pp. 172–82, Dec. 2014.

A. Rivas-Aravena, Y. Fuentes, J. Cartagena, T. Brito, V. Poggio, J. La Torre, H. Mendoza, F. Gonzalez-Nilo, A. M. Sandino, and E. Spencer, “Development of a nanoparticle-based oral vaccine for Atlantic salmon against ISAV using an alphavirus replicon as adjuvant.,” Fish Shellfish Immunol., vol. 45, no. 1, pp. 157–66, Jul. 2015.

F. E. Reyes-López, J. S. Romeo, E. Vallejos-Vidal, S. Reyes-Cerpa, A. M. Sandino, L. Tort, S. Mackenzie, and M. Imarai, “Differential immune gene expression profiles in susceptible and resistant full-sibling families of Atlantic salmon (Salmo salar) challenged with infectious pancreatic necrosis virus (IPNV).,” Dev. Comp. Immunol., vol. 53, no. 1, pp. 210–21, Nov. 2015.

A. Rivas-Aravena, S. Guajardo, B. Valenzuela, J. Cartagena, M. I. Imarai, E. Spencer, and A. M. Sandino, “Ribavirin stimulates the immune response of Atlantic salmon.,” Vet. Immunol. Immunopathol., vol. 164, no. 1–2, pp. 93–100, Mar. 2015.

B. Valenzuela, M. Imarai, R. Catalan, M. Parra, S. Soto, A. M. Sandino, R. Torres, and B. Modak, “Evaluation of the bactericidal activity of secondary metabolites isolated from Heliotropium genus ag ainst Piscirickettsia salmonis,” Boletín Latinoam. y del Caribe Plantas Med. y Aromáticas, vol. 14, no. 2, pp. 131–140, 2015.

Nardocci G, Navarro C, Cortés PP, Imarai M, Montoya M, Valenzuela B, et al. Neuroendocrine mechanisms for immune system regulation during stress in fish. Fish Shellfish Immunol. 2014;40: 531–8. doi:10.1016/j.fsi.2014.08.001

Montoya M, Cortez-San Martin M, Acuña C, Mejias S, Ahumada V. Solicitud de patente: Uso de extracto de Hypericum perforatum para mejorar las barreras antioxidantes endogenas, la sobrevida y condiciones generales de peces en la industria acuicola, y su uso para tratar peces afectados por eventos estresantes y evitar . 7962015, 2015.

Escobar A, Candia E, Reyes-Cerpa S, Villegas-Valdes B, Neira T, Lopez M, et al. Neisseria gonorrhoeae induces a tolerogenic phenotype in macrophages to modulate host immunity. Mediators Inflamm. 2013;2013: 127017. doi:10.1155/2013/127017

Reyes-Cerpa S, Maisey K, Reyes-López F, Toro-Ascuy D, Sandino AM, Imarai M. Fish Cytokines and Immune Response. In: Turker H, editor. New Advances and Contributions to Fish Biology. InTech; 2012. doi:10.5772/45635

Reyes-Cerpa S, Reyes-López FE, Toro-Ascuy D, Ibañez J, Maisey K, Sandino AM, et al. IPNV modulation of pro and anti-inflammatory cytokine expression in Atlantic salmon might help the establishment of infection and persistence. Fish Shellfish Immunol. 2012;32: 291–300. doi:10.1016/j.fsi.2011.11.018

Reyes-Cerpa S, Reyes-López F, Toro-Ascuy D, Montero R, Maisey K, Acuña-Castillo C, et al. Induction of anti-inflammatory cytokine expression by IPNV in persistent infection. Fish Shellfish Immunol. 2014;41: 172–82. doi:10.1016/j.fsi.2014.08.029

Reyes-López FE, Romeo JS, Vallejos-Vidal E, Reyes-Cerpa S, Sandino AM, Tort L, et al. Differential immune gene expression profiles in susceptible and resistant full-sibling families of Atlantic salmon (Salmo salar) challenged with infectious pancreatic necrosis virus (IPNV). Dev Comp Immunol. 2015;53: 210–21. doi:10.1016/j.dci.2015.06.017

Molina-Quiroz RC, Silva CA, Molina CF, Leiva LE, Reyes-Cerpa S, Contreras I, et al. Exposure to sub-inhibitory concentrations of cefotaxime enhances the systemic colonization of Salmonella Typhimurium in BALB/c mice. Open Biol. 2015;5. doi:10.1098/rsob.150070

Lagos R, Tello M, Mercado G, García V, Monasterio O. Antibacterial and antitumorigenic properties of microcin E492, a pore-forming bacteriocin. Curr Pharm Biotechnol. 2009;10: 74–85.

Cottet L, Cortez-San Martin M, Tello M, Olivares E, Rivas-Aravena A, Vallejos E, et al. Bioinformatic analysis of the genome of infectious salmon anemia virus associated with outbreaks with high mortality in Chile. J Virol. 2010;84: 11916–28. doi:10.1128/JVI.01202-10

Corsini G, Karahanian E, Tello M, Fernandez K, Rivero D, Saavedra JM, et al. Purification and characterization of the antimicrobial peptide microcin N. FEMS Microbiology Letters. 2010. pp. 119–125.

Rivas-Aravena A, Vallejos-Vidal E, Cortez-San Martin M, Reyes-Lopez F, Tello M, Mora P, et al. Inhibitory effect of a nucleotide analog on infectious salmon anemia virus infection. J Virol. 2011;85: 8037–8045.

Tello M, Saavedra JM, Spencer E. Analysis of the use of codon pairs in the HE gene of the ISA virus shows a correlation between bias in HPR codon-pair use and mortality rates caused by the virus. Virol J. 2013;10: 180. doi:10.1186/1743-422X-10-180

Tello M, Vergara F, Spencer E. Genomic adaptation of the ISA virus to Salmo salar codon usage. Virol J. 2013;10: 223. doi:10.1186/1743-422X-10-223

2014

A complete computational framework for metagenomic strain identification in environmental or clinical sequencing samples. Changjin Hong, Solaiappan Manimaran, Ying Shen, Joseph F. Perez-Rogers, Allyson L. Byrd, Eduardo Castro-Nallar, Keith A. Crandall, and W. Evan Johnson. 2014. PathoScope 2.0: Microbiome. 2 (1), 1-15

Alternative genomic survey tools for molecular epidemiology and pathology. Eduardo Castro-Nallar, Nur Hasan, Richard Robison, Rita Colwell, W. Evan Johnson, and Keith A. Crandall. 2014.. PeerJ. Accepted

Clinical PathoScope: Rapid alignment and filtration for accurate pathogen identification in clinical samples using unassembled sequencing data. Allyson L. Byrd, Joseph F. Perez-Rogers, Changjin Hong, Solaiappan Manimaran, Eduardo Castro-Nallar, Ian Toma, Tim McCaffrey, Marc Siegel, Gary Benson, Keith A. Crandall, W. Evan Johnson. 2014. BMC Bioinformatics. 15 (1), 262

Derivatives of 3 H-spiro1-benzofuran-2, 1’-cyclohexanes: Immunostimulants for veterinary use. Modak.B, Torres.P, Mascayano-C, Torres.R, Urzúa.A, Valenzuela.B.. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas 13, 375 – 380, 2014.

Development of A Reverse Genetic System for Infectious Salmon Anemia Virus (ISAV): Rescue of Recombinant Fluorescence Virus Using Salmon ITS-1 Region as a Novel Promoter. Daniela Toro-Ascuy, Carolina Tambley, Carolina Beltran, Carolina Mascayano, Nicolas Sandoval, Eduardo Olivares, Rafael A. Medina, Eugenio Spencer and *Marcelo Cortez-San Martin. Applied and environmental microbiology. Appl Environ Microbiol. 2014 Dec 5. pii: AEM.03153-14. [Epub ahead of print]

Development of plaque assay for Infectious Salmon Anemia Virus (ISAV), application for virus purification and titration in salmon ASK cells . Castilllo, M.T., Cottet,L., Toro-Ascuy, D. Spencer, E. and Cortez-San Matín, M. Journal of Fish Diseases (2014) 37: 989-995

Draft Genome Sequence of the Chilean isolate Aeromonas salmonicida strain CBA10. 2014. Valdes N., Espinoza C., Sanhueza L., Gonzalez A., Corsini G., Tello M.* FEMS Microbiol letters, Aceptado.

Induction of anti-inflammatory cytokine expression by IPNV in persistent infection. Reyes-Cerpa S, Reyes-López F, Toro-Ascuy D, Montero R, Maisey K, Acuña-Castillo C, Sunyer JO, Parra D, Sandino AM, Imarai M. Fish Shellfish Immunol. 2014 Sep 2;41(2):172-182.

Neuroendocrine mechanisms for immune system regulation during stress in fish. Nardocci G, Navarro C, Cortés PP, Imarai M, Montoya M, Valenzuela B, Jara P, Acuña-Castillo C, Fernández R. Fish Shellfish Immunol. 2014 Oct;40(2):531-8.

Pantoeaagglomerans an agent to remove residual copper from aquaculture activity Pradel P., Corsini G., Tello M. y González A.* Advanced Materials Research Vols. 945-949 (2014) pp 3479-3482.

Prevalence of R5 and X4 HIV variants in antiretroviral treatment experienced patients with virologic failure P. Ferrero, M. Tello, L. Montecinos, R. Tordecilla, C. Rodríguez, C. Beltrán, M.A. Guzmán, M. Ferrés, C.M. Pérez, A. Afani J Clin Virol. 2014 Apr 15. pii: S1386-6532(14)00136-X. doi: 10.1016/j.jcv.2014.04.004.

Single-Molecule Long Read 16S Sequencing to Characterize the Lung Microbiome from Mechanically Ventilated Patients with Suspected Pneumonia. Ian Toma, Marc O. Siegel, John Keiser, Anna Yakovleva, Alvin Kim, Lionel Davenport, Joseph Devaney, Eric P. Hoffman, Rami Alsubail, Keith A. Crandall, Eduardo Castro-Nallar, Marcos Pérez-Losada, Sarah Hilton, Lakhmir S. Chawla, Timothy A. McCaffrey, and Gary L. Simon. 2014. Journal of Clinical Microbiology. 52 (11), 3913-3921

Tolerogenic dendritic cells derived from donors with natural rubber latex allergy modulate allergen-specific T-cell responses and IgE production. Escobar A, Aguirre A, Guzmán MA, González R, Catalán D, Acuña-Castillo C, Larrondo M, López M, Pesce B, Rolland J, O`Hehir R, Aguillón JC PLoS One. 2014 Jan 22;9(1):e85930.

Toxin-Antitoxin Systems in the Mobile Genome of Acidithiobacillus ferrooxidans Bustamante P., Tello M., Orellana O.* PLoS One. 2014 Nov 10;9(11):e112226. doi: 10.1371/journal.pone.0112226. eCollection 2014.

Whole genome single-nucleotide variation profile-based phylogenetic tree building methods for analysis of viral, bacterial and human genomes. Faison, W. J., Rostovtsev, A., Castro-Nallar, E., Crandall, K. A., Chumakov, K., Simonyan, V., & Mazumder, R. 2014. Genomics. 104(1):1-7

2013

Analysis of the use of codon pairs in the HE gene of the ISA virus shows a correlation between bias in HPR codon-pair use and mortality rates caused by the virus. Tello,M., Saavedra, J.M. and Spencer, E. Virology Journal 10:180 (2013).

Coumarins of Haplopappus multifolius and derivate as inhibitor of LOX: evaluation in vitro and docking studies. Torres.R, Mascayano.C, Núñez.C, Modak.B, Faini.F. J.Chil.Chem.Soc., 58,1842, 2013.

Genomic adaptation of the ISA virus to Salmo salar codon usage. Mario Tello, Francisco Vergara and Eugenio Spencer. Virology Journal 10: 223 (2013).

HIV-1 tropism: a comparison between RNA and proviral DNA in routine clinical samples from Chilean patients. Ferrer P.*, Montecinos L., Tello M., Tordecilla R, Rodríguez C., Ferrés M., Pérez CM., Beltrán C., Guzmán MA., Afani A.. Virol J. 2013 Oct 28;10(1):318.

Immunomodulatory effects of the aromatic geranyl derivative Filifolinone tested by the induction of cytokine expression. Valenzuela.B, Imarai.M, Torres.R, Modak.B. Developmental and Comparative Immunology, 41, 675-682, 2013.

Nanoparticles and microparticles of polymers and polysaccharides to administer fish vaccines” Rivas, A, Sandino,A.M. y Spencer, E, Biological Research 46: 407-419 (2013).

Natural killer cell cytotoxicity is not regulated by folic acid in vitro. Sandra Hirsch, Dante Miranda, Estefania Munoz, Margarita Montoya, Ana María Ronco, MP de la Maza, Daniel Bunout. (2013) Nutrition. 29(5):772-6.

Pathogen typing in the genomics era: MLST and the future of molecular epidemiology. Pérez-Losada, M., Cabezas, P., Castro-Nallar, E., Crandall, K. 2013. Infection, Genetics, and Evolution.16:6, 38-53.

Pathoscope: Species identification and strain attribution with unassembled sequencing data. Owen E. Francis, Matthew Bendall, Solaiappan Manimaran, Changjin Hong, Nathan L. Clement, Eduardo Castro-Nallar, Quinn Snell, G. Bruce Schaalje, Mark J. Clement, Keith A. Crandall, and W. Evan Johnson. 2013. Genome Res. 23(10):1721-9.

Phage cluster relationships identified through single gene analysis. Smith, K. C., Castro-Nallar, E., Fisher, J. N., Breakwell, D. P., Grose, J. H., & Burnett, S. H. (2013). BMC Genomics, 14:410.

Soluble b-1,3/1,6-glucan in seaweed from the southern hemisphere and its immunomodulatory effect. Francisca Bobadilla, Carolina Rodriguez-Tirado, Mónica Imarai, María José Galotto, Roger Andersson. Carbohydr Polym. 2013 92 (1): 241-248.

Staphylococcus equorum isolated from seabed as potential biotool to Cr(VI) remediation Pradel, P., Hernández, C., Tello, M., Villarroel, M.P., Corsini, G., González, A.* (2013) Advanced Materials Research 825 PP. 524 – 527.

Tat Exon 1 Exhibits Functional Diversity During HIV-1 Subtype C Primary Infection. Raabya Rossenkhan, Iain MacLeod, Theresa Sebunya, Eduardo Castro-Nallar, Mary McLane, Rosemary Musonda, Berhanu Gashe, Vlad Novitsky, and M. Essex. 2013. Journal of Virology. 87(10), 5732-5745.

2012

Antioxidant activity of Resinous Exudates and its majority component isolated from Heliotropium stenophylum and H. sinuatum in heterogeneous and homogeneous system. Campos. A, Lissi E, Chavez.M, Modak .B.. BLACPMA, 11, 549-555, 2012.

Antiviral activity in vitro and in vivo of natural flavonoids isolated from Heliotropium sinuatum against infectious salmon anemia virus (ISAV). Modak.B, Rivas.A, Vallejos.E, Sandino.A.M, Spencer.E. BLACPMA, 11,377-384, 2012.

Comparative genomics of Ceriporiopsis subvermispora and Phanerochaete chrysosporium provide insight into selective ligninolysis Fernandez-Fueyo E, Ruiz-Dueñas FJ, Ferreira P, Floudas D, Hibbett DS, Canessa P, Larrondo LF, James TY, Seelenfreund D, Lobos S, Polanco R, Tello M, Honda Y, Watanabe T, Watanabe T, Ryu JS, Kubicek CP, Schmoll M, Gaskell J, Hammel KE, St John FJ, Vanden Wymelenberg A, Sabat G, Splinter BonDurant S, Syed K, Yadav JS, Doddapaneni H, Subramanian V, Lavín JL, Oguiza JA, Perez G, Pisabarro AG, Ramirez L, Santoyo F, Master E, Coutinho PM, Henrissat B, Lombard V, Magnuson JK, Kües U, Hori C, Igarashi K, Samejima M, Held BW, Barry KW, LaButti KM, Lapidus A, Lindquist EA, Lucas SM, Riley R, Salamov AA, Hoffmeister D, Schwenk D, Hadar Y, Yarden O, de Vries RP, Wiebenga A, Stenlid J, Eastwood D, Grigoriev IV, Berka RM, Blanchette RA, Kersten P, Martinez AT, Vicuna R*, Cullen D.* Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5458-63.

Effect of supraphysiological concentration of serum folate on natural killer cell activity in healthy subjects. Hirsch S, Miranda D, Fuentes C, Leiva L, Barrera G, Montoya M, Ronco AM, de la Maza MP, Bunout D (2012) e-SPEN Journal. 7:e125-e128.

Genetic diversity and molecular epidemiology of HIV transmission. Castro-Nallar, E., Crandall, K.A., Perez-Losada, M., 2012. Future Virology 7, 239-252.

In vitro immunostimulant activity of the aromatic geranyl derivative Filifolinone. Brenda Modak, Beatriz Valenzuela, Mónica Imarai, René Torres. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas 2012 11 (3): 285-290.

Infectivity study of Streptococcus phocae to seven fish and mammal cell lines by confocal microscopy. Cortez-San Martin M, González-Contreras A, *Avendaño-Herrera R. Journal of Fish Diseases. 2012 Jun;35(6):431-6. doi: 10.1111/j.1365-2761.2012.01361.x. Epub 2012 Apr 23.

IPNV modulation of pro and anti-inflammatory cytokine expression in Atlantic salmon might help the establishment of infection and persistence. Reyes-Cerpa S, Reyes-López F, Toro Ascuy D., Maisey K. , Ibañez J., Sandino A. and Imarai M. Fish and Shellfish Immunology, 32 (2): 291-300, 2012.

Polymyxin B increases the depletion of T regulatory cell induced by purinergic agonist. Cappelli C, López X, Labra Y, Montoya M, Fernández R, Imarai M, Rojas JL, Miranda D, Escobar A, Acuña-Castillo C. (2012) Immunobiology. 217:307-15.

Population Genomics and Phylogeography of an Australian Dairy Factory Derived Lytic Bacteriophage. Castro-Nallar, E., Chen, H., Gladman, S., Moore, S.C., Seemann, T., Powell, I.B., Hillier, A., Crandall, K.A., Chandry, P.S., 2012. Genome Biol Evol. 4(3):382-93.

Reduction of monounsatured fatty acid content of E. coli K-12 results in increased resistance to oxidative damage. Pradenas GA., Paillavil PA., Reyes-Cerpa S., Pérez JM., Vazques CC. Microbiology 2012. 158(Pt 5):1279-83.

Simultaneous detection of the IPN and ISA viruses in outbreaks of clinical disease and mortality in farmed Atlantic salmon, Salmo salar L., in Chile. Cortez-San Martín, M., Rivas-Aravena, A., Guajardo S., Jashes M., Sandino, A.M. and Spencer, E. Journal of Fish Diseases; 35 (6): 461-465, 2012.

The evolution of HIV: inferences using phylogenetics. Castro-Nallar, E., Perez-Losada, M., Burton, G.F., Crandall, K.A., 2012. Molecular Phylogenetics and Evolution 62, 777-792.

2011

Diversity of teleost leukocyte molecules: role of alternative splicing. Maisey K, Imarai M. Fish Shellfish Immunol. 2011 Nov; 31(5):663-72. Review.

Identification of CD3ε, CD4, CD8β splice variants of Atlantic salmon. Maisey K, Toro-Ascuy D, Montero R, Reyes-López FE, Imarai M. Fish Shellfish Immunol. 2011 Dec; 31(6):815-22.

In vitro antiproliferative activity of 3 H-spiro (1-benzofuran-2,1’-ciclohexane) derivatives. Modak. B, Torres.R, De Saint Pierre.M, Saud.K, Armijo.A, Caviedes.R y Caviedes.P. BLACPMA, 10, 281-288, 2011.

Infectious salmon anemia virus-Genetics and pathogenesis. Cottet L, Rivas-Aravena A, Cortez-San Martin M, Sandino AM, Spencer E. Virus Research. 2011. Jan; 155(1):10-9.

Inhibitory effect of a nucleotide analog on ISAV infection. Rivas-Aravena A, Vallejos-Vidal E, Cortez-San Martin M, Reyes-Lopez F, Tello M, Mora P, Sandino AM, Spencer E. Journal of Virology. 2011. Aug; 85(16):8037-45

Lipopolysaccharide Inhibits the Channel Activity of the P2X7 Receptor, Mediators of Inflammation. Leiva-Salcedo E, Coddou C, Rodríguez FE, Lopez X, Penna A, Neira T, Fernandez R, Imarai M, Rios M, Rios M, Escobar J, Montoya M, Huidobro-Toro JP, Escobar A, Acuña-Castillo C., vol. 2011, Article ID 152625, 12 pages, 2011. doi:10.1155/2011/152625.

Molecular phylodynamics and protein modeling of infectious salmon anemia virus (ISAV).Castro-Nallar, E., Cortez-San Martin, M., Mascayano, C., Molina, C., Crandall, K.A., 2011. BMC Evolutionary Biology 11, 349.

Naturals antivirals in the Aquaculture industry: a challenge to Phytotherapy. Modak.B. “.Editorial BLACPMA, 10, 290-293, 2011.

Seasonal variation of the flavonoids pinocembrin and 3-O-methylgalangin, in the surface component mixture (resinous exudates and waxy coating) of Heliotropium stenophyllum. Modak. B, Torres.R y Urzúa. A. J.Chil.Chem.Soc., 56,532-534,2011.

Solid State Structure and Absolute Configuration of Filifolinol Acetate. Muñoz. M, Urzúa .A, Echeverría.J, Modak .B and Joseph-Nathan.P. Natural Product Communications, 6, 759-762, 2011.

2010

Bioinformatic analysis of the genome of infectious salmon anemia virus associated with outbreaks with high mortality in Chile.” Cottet L., Cortez-San Martin M.*, Tello M., Olivares E., Rivas-Aravena A., Vallejos E., Sandino AM., Spencer E. Journal of Virology, (2010) 84(22):11916-28.

Inhibitory Effect of Aromatic Geranyl Derivatives isolated from Heliotropium filifolium on Infectious Pancreatic Necrosis Virus Replication. Modak B., Sandino A.M., Arata L., Cárdenas-Jirón G. and Torres R. Veterinary Microbiology, 141, 53-58, 2010.

Purification and characterization of the antimicrobial peptide microcin N. Corsini G.*, Karahanian E., Tello M., Fernandez K., Rivero D., Saavedra JM., Ferrer A. FEMS Microbiol Lett. (2010) 312(2):119-25.

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